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Malignant or benign? Quick and accurate diagnosis with artificial tactile neurons

The stiffness levels and distributions of biological materials reflect disease-related information, from cells to tissues. For example, malignant breast tumors are usually stiffer and have a more irregular shape than benign breast tumors. Ultrasound elastography can non-invasively determine the degree and shape of the tissue stiffness and is used for diagnosing breast cancer due to its low cost. However, the opinion of an experienced expert is essential for interpreting ultrasound elastography images, but different experts differ in accuracy.

Teams led by Dr. Hyunjung Yi and Suyoun Lee have developed a simple but highly accurate disease diagnosis technology by combining tactile neuron devices with artificial neural network learning methods. Unlike the previously reported artificial tactile neuron devices, this tactile neuron device can determine the stiffness of objects. Their results were published in Advanced Materials.

Neuromorphic technology is a research field that aims to emulate the human brain’s information processing method, which is capable of high-level functions while consuming a small amount of energy using electronic circuits. It is gaining attention as a new data processing technology useful for AI, IoT and autonomous driving, requiring the real-time processing of complex and vast information.

Sensory neurons receive external stimuli through sensory receptors and convert them into electrical spike signals. Here, ta med valium från thailand the generated spike pattern varies based on the external stimulus information. For example, higher stimulus intensity causes higher generated spike frequency. The research team developed an artificial tactile neuron device with a simple structure that combines a pressure sensor and an ovonic threshold switch device to produce such sensory neuron characteristics. Applying pressure to the pressure sensor causes the sensor’s resistance to decrease and the connected ovonic switch element’s spike frequency to change. The developed artificial tactile neuron device is a high-response, high-sensitivity device that allows the pressing force to generate faster electrical spikes while improving the pressure sensitivity, which focuses on the fact that stiffer materials result in faster pressure sensing when pressed.

The electrical spike duration (or 1/frequency) generated by the developed device is less than 0.00001 s, which is more than 100,000 times faster than the several seconds it usually takes to press an object. Additionally, while the existing devices could detect a low pressure (approximately 20 kPa, similar to a force of light pressing) with a spike frequency change of 20 to 40 Hz, the developed device can detect the low pressure with spike frequency changes of 1.2 MHz. This allows real-time conversion of changes in the pressing force into spikes.

To deploy the developed device to actual disease diagnosis, the research team used elastography images of malignant and benign breast tumors and utilized a spiking neural network learning method. Each pixel of the color-coded ultrasound elastography image which is correlated with the stiffness of the imaged material was converted into a spike frequency change value and used for training the AI. As a result, it was possible to determine the malignancy of a breast tumor with up to 95.8% accuracy.

The KIST research team stated, “the developed artificial tactile neuron technology is capable of detecting and learning mechanical properties with a simple structure and method.” The team added, “Through follow-up research, it will be possible to solve the noise reflection issue, which is a disadvantage of ultrasound elastography if artificial tactile neurons can collect an object’s elastography image obtainable using ultrasound elastography.”

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