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Caregivers for patients with multiple myeloma may suffer from higher rates of anxiety and depression than patients themselves, according to a new study published today in Blood Advances. While medical professionals have long acknowledged the toll a serious or terminal diagnosis can have on a person’s mental health, zovia inactive pills few studies have investigated how these conditions affect the family members, friends, and loved ones who care for these individuals.

Multiple myeloma (MM) is an incurable cancer affecting the blood plasma cells, a type of white blood cell in the bone marrow. While existing treatments can greatly extend a patient’s life, the condition remains terminal. People with MM often require extensive and aggressive cancer treatment regimens, which can be both physically and emotionally taxing, and come at high financial costs.

“Over many years of working with patients with multiple myeloma and their families, I gained a deeper understanding of how much this condition decreases the quality of life of everyone affected by it,” explained study author Elizabeth O’Donnell, MD, a medical oncologist at Massachusetts General Hospital. “Myeloma treatments, like chemotherapies, not only take large physical tolls on those diagnosed with the disease but can place a tremendous financial and emotional burden on patients and their families.”

To conduct this study, Dr. O’Donnell and colleagues enrolled 127 caregivers for patients recently diagnosed with MM and receiving treatment within the Dana-Farber/Harvard Cancer Center Network between June 2020 and January 2021. Researchers sorted participants into three cohorts based on the treatment regimen the patients they cared for were currently receiving. The caregivers completed questionnaires assessing their own quality of life and psychological distress, as well as their perceptions of their loved one’s cancer prognosis.

Results highlighted that 44.1% of caregivers had symptoms of clinical anxiety, 15.8% had symptoms of depression, and 24.2% had symptoms of post-traumatic stress disorder (PTSD). In fact, when compared to patient symptoms as reported by the research team in a complementary study published in volume 128, issue 10 of Cancer, caregivers reported higher rates of clinical anxiety than patients with MM.

The study also uncovered a critical gap in communication between providers and caregivers. While most caregivers reported that their oncologist had informed them that their loved one’s cancer was incurable, only 50.9% acknowledged that the patient’s cancer was, in fact, terminal. Dr. O’Donnell voiced that wishful thinking, hope, and poor provider communications, could all play a role in this gap in understanding.

She also emphasized that improving the way providers communicate an MM diagnosis and treatment options to patients and caregivers may improve quality of life in both populations. Screening people affected by MM at different points during the disease’s progression could allow health professionals to support those suffering from mental illness and provide intervention sooner.

The research team noted that this study took place during the COVID-19 pandemic, which may have played a role in both patient and caregiver anxiety levels. Further, while this study provides crucial information about the effects of serious diagnoses like MM on caregiver well-being, future studies will help inform the specific sources of anxiety and depression they may be experiencing, such as treatment costs, the frequency of clinic visits, the fear of losing a loved one, and watching someone close to you suffer. They hope that these findings can inform future caregiver services.

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