how long for lexapro to work
Myelofibrosis is a rare condition affecting the bone marrow. Following initial overproduction of blood cells, scar tissue builds up inside the bone marrow. Although it can affect people at any age, it most commonly develops in people over the age of 50.
What causes myelofibrosis?
Myelofibrosis develops in the bone marrow, where stem cells produce the main three types of blood cell: white blood cells, red blood cells, and platelets. When the bone marrow is overactive, how to buy tegretol pharm support group without prescription scar tissue builds up in the marrow and its ability to produce blood cells is impaired. This can lead to blood cells being produced in the spleen and liver instead.
Although the exact cause of myelofibrosis is not fully understood, mutations in several specific genes have been implicated in MF. These genes include JAK2, CALR, and MPL. It is estimated that approximately 65 percent of people diagnosed with myelofibrosis will have faults in the JAK2 gene, with 25 percent possessing faults in the CALR gene, and up to 8 percent with faults in the MPL gene.
Faults can occur in genes when cells divide and the chromosomes in the new cells are not the same as those the original cell. Faults can occur in the JAK2 and MPL genes after exposure to dangerous chemicals, but faults in JAK2, CALR, and MPL are typically due to errors made when the cell divides.
Complications caused by blood cell production in the liver and spleen
The spleen and liver cannot produce cells as effectively as bone marrow. As a result, patients with myelofibrosis can develop anemia, a condition in which there are not enough red blood cells in the blood.
The spleen may also retain some of the red blood cells it produces instead of releasing them into the blood, which can cause the spleen to become enlarged. This often produces symptoms.
Symptoms of myelofibrosis
Myelofibrosis does not always present any symptoms, but symptoms that do occur are usually due to a low blood cell count, or an enlarged spleen.
Symptoms can include:
- Recurrent infections
- Shortness of breath
- Fevers and night sweats
- Weight loss
- Gout (inflammation of the joints)
- Abnormal bleeding and bruising.
Abnormal bleeding and bruising covers:
- Abnormal vaginal bleeding in women
- Bleeding gums.
Symptoms that are indicative of an enlarged spleen including abdominal pain, typically on the left side, and sometimes patients will feel full very quickly after eating.
Diagnosis of myelofibrosis
As myelofibrosis is often asymptomatic, patients are often diagnosed when they have a blood test for another, unrelated reason. If patients are presenting symptoms that indicate a possible case of myelofibrosis, a full blood count can be taken to measure the number of the different blood cells that are present in the blood. Red blood cells that present an abnormal shape may suggest that myelofibrosis has developed.
There are also a number of other diagnostic tests available to confirm cases of myelofibrosis.
There is a specific blood test available that will check for mutations in the JAK2, CALR, and MPL genes. It’s estimated that approximately 50 percent of patients with myelofibrosis have faults in the JAK2 gene, and 30 percent have a fault in the CALR gene. However, not everyone will have these faults, so these genetic tests cannot always confirm the presence of myelofibrosis.
Tests to the bone marrow itself can also be used in diagnostic tests for myelofibrosis and to check that no other bone marrow problems are present. A bone marrow biopsy can be taken from the pelvis, which involves liquid marrow being extracted through a small needle (a bone marrow aspirate). A bone marrow sample can also be taken from the bone itself. Biopsies provide information on the bone marrow structure and the number and distribution of the different blood cells within the marrow. It can also identify any cancerous cells that are present.
Risk factors for myelofibrosis
Additional to the presence of JAK2, CALR, or MPL genes, patients may be at a higher risk of developing myelofibrosis if they match with the following risk factors. These include increased age, as myelofibrosis typically develops in those between the ages of 50 and 70, and a previous diagnosis of polycythemia vera or essential thrombocythemia, two genetic conditions affecting the bone marrow that can cause fibrosis (scarring) in the bone marrow.
There does not seem to be a bias between sexes in myelofibrosis, and men and women are equally at risk of developing the condition.
Patients with myelofibrosis are also at an increased risk of developing thrombosis, commonly known as blood clots. Blood clots are serious, and can form in the brain, eyes, heart, and abdomen. Blood clots can also form in the veins of the legs in a condition called deep vein thrombosis (DVT).
Stages of myelofibrosis
Once a patient has a positive diagnosis of myelofibrosis the disease progression will be assessed, which is categorized into three stages.
Early proliferative (cellular) phase
In this phase, the bone marrow will be overactive and will contain high numbers of megakaryocytes, which are stem cells that produce platelets. The amount of fibrin, the protein that is produced when blood clots and inhibits blood flow through the fibrous network, will also be present in high amounts. Blood counts will also be high in this phase of MF.
The fibrotic phase is characterized by an increased amount of fibrosis in the bone marrow, and a decrease in the amount of blood-forming tissue. A reduction in mature red blood cells, white blood cells, and platelets may also occur due to the change in bone marrow structure.
Acute myeloid leukemia
Some patients will have their myelofibrosis progress to acute myeloid leukemia, which is a type of blood cancer that affects the myeloid blood cells, including red blood cells, platelets, and certain types of white blood cell.
Treatments for myelofibrosis
Blood counts, the range of symptoms, and a patient’s overall fitness will determine which treatments will be suitable. Typically, treatments aim to control symptoms of the condition. If MF is asymptomatic, treatments may not be started immediately after diagnosis, with patients being monitored with regular blood tests.
If a patient is experiencing severe anemia due to MF, regular blood transfusion may be necessary every one to three months. Platelet transfusions may also be necessary if abnormal bleeding is occurring and if platelet counts are low.
Local radiation may be used to treat an enlarged spleen, which will reduce the size of the spleen for a period of several months to approximately two years. Removing the spleen is also an option, a procedure also called a splenectomy. However, splenectomise can result in complications after the surgery.
Chemotherapy drugs can be used to reduce the amount of red blood cells being produced, which, as with any chemotherapy treatment, will produce side effects. It is important to note that it is speculated certain chemotherapy treatments for MF may increase the chances of it progressing to acute myeloid leukemia if they are used for a long period of time.
Additionally, there are JAK2 inhibitors that can reduce the size of the spleen and reduce the severity of any MF-related symptoms, but they can increase a patient’s risk of anemia.
A stem cell transplant can be carried out to increase the number of healthy stem cells that can then produce normal blood cells. However, there are risks associated with the procedure and most patients with myelofibrosis are not treated with a stem cell transplant. The two types of stem cell transplants are autologous (also known as autograft), which uses the patients’ own stem cells, and allogeneic (also known as allograft), which uses donor stem cells and poses significant risk to the patient.
What is the prognosis for myelofibrosis?
Prognosis for myelofibrosis is varied, with some cases of MF progressing rapidly, and others progressing more slowly. It has been estimated that approximately one quarter of patients with myelofibrosis may progress to acute myeloid leukemia.
- All Myelofibrosis Content
Last Updated: Apr 26, 2019
Lois is a freelance copywriter based in the UK. She graduated from the University of Sussex with a BA in Media Practice, having specialized in screenwriting. She maintains a focus on anxiety disorders and depression and aims to explore other areas of mental health including dissociative disorders such as maladaptive daydreaming.
Source: Read Full Article