naproxen before running left hippocampus (LH), and right hippocampus (RH). (c) Electrical activity is detected in all four regions upon hyperthermia exposure. (d) The percent of mice that show behavioral convulsions under hyperthermia at the different temperatures. (e) cFos expression in the cortex and dentate gyrus of normothermic and hyperthermic conditions as well as with microglial depletion. (f) Efficient microglial elimination with PLX3397 treatment in developing mice. (g–i) Microglial elimination and its effects of time to the first seizures (g) percent of mice that seize at 41°C (h) and mortality rate (i) during hyperthermia-induced seizures in developing mice. n = 13 mice per group. Statistics calculated by Student’s t-test and χ2 with Fisher’s exact test in (i). **p < .01; ****p < .0001. Credit: Glia (2023). DOI: 10.1002/glia.24364″ width=”800″ height=”530″>

Understanding seizures

Source: Read Full Article